Inflamation and Innate Immunity Research Core
Director: Martha Monick, Ph.D.
Internal Medicine
Co-Leader: Paul B. McCray, Jr., M.D.
Internal Medicine
The primary goal of the Inflammation and Innate Immunity Research Core (IIIRC) is to serve as the intellectual home for EHSRC members whose research is focused on mechanisms of immune responses and to link these investigators with the rest of the EHSRC. Although the expertise of many is centered on airway inflammation, others focus on innate mechanisms relevant to systemic immune responses. Some of these studies are directly linked with environmental exposures (e.g. transduction of the effects of agricultural bioaerosols and endotoxin inhalation; environmental risk factors for sarcoidosis), whereas others relate to modulation of innate immune responses (e.g. βdefensins and other innate immune response elements) or host susceptibility to environmentally encountered agents (e.g. biofilm modulation of responses to inhaled bacteria).
Specific Aims
The following aims will be pursued in the next five years in the area of Inflammation and Innate Immunity research:
Aim 1: Promote research on inflammatory and immune mechanisms relevant to and responsible for the health effects of agricultural and rural exposures
Aim 2: Promote and enhance training in the disciplines of inflammation and immunology that are relevant to environmentally-related lung disease; encourage trainees to pursue studies in related areas of research
Aim 3: Serve as a national resource in inflammation and immunology for mechanistic studies related to agricultural and rural exposures
Members:
Michael A. Apicella, PhD
Microbiology
Botond Banfi, MD, PhD
Anatomy and Cell Biology
Eric A. Hoffman, PhD
Radiology
Gail Bishop, PhD
Microbiology
A. Brent Carter, MD
Internal Medicine
Alejandro Comellas, MD (associate member)
Internal Medicine
Beverly L. Davidson, PhD
Anatomy and Cell Biology
Internal Medicine
John Engelhardt, PhD
Internal Medicine
Alicia Gerke, MD, MBA (associate member)
Internal Medicine
Paul B. McCray, Jr., MD
Internal Medicine
Martha M. Monick, PhD
Internal Medicine
William M. Nauseef, MD
Internal Medicine
Paul B. Rothman, MD
Internal Medicine
Fayyaz S. Sutterwala, MD, PhD
Internal Medicine
Occupational & Environmental Health
Jerrold P. Weiss, MD
Internal Medicine & Microbiology
Michael J. Welsh, MD
Internal Medicine
Joseph Zabner, MD
Internal Medicine

