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Inflamation and Innate Immunity Research Core

Director: Martha Monick, Ph.D.
Internal Medicine

Co-Leader: Paul B. McCray, Jr., M.D.
Internal Medicine

The primary goal of the Inflammation and Innate Immunity Research Core (IIIRC) is to serve as the intellectual home for EHSRC members whose research is focused on mechanisms of immune responses and to link these investigators with the rest of the EHSRC. Although the expertise of many is centered on airway inflammation, others focus on innate mechanisms relevant to systemic immune responses. Some of these studies are directly linked with environmental exposures (e.g. transduction of the effects of agricultural bioaerosols and endotoxin inhalation; environmental risk factors for sarcoidosis), whereas others relate to modulation of innate immune responses (e.g. β­defensins and other innate immune response elements) or host susceptibility to environmentally encountered agents (e.g. biofilm modulation of responses to inhaled bacteria).

Specific Aims

The following aims will be pursued in the next five years in the area of Inflammation and Innate Immunity research:

Aim 1: Promote research on inflammatory and immune mechanisms relevant to and responsible for the health effects of agricultural and rural exposures

Aim 2: Promote and enhance training in the disciplines of inflammation and immunology that are relevant to environmentally-related lung disease; encourage trainees to pursue studies in related areas of research

Aim 3: Serve as a national resource in inflammation and immunology for mechanistic studies related to agricultural and rural exposures

Members:

Michael A. Apicella, PhD
Microbiology

Botond Banfi, MD, PhD
Anatomy and Cell Biology

Eric A. Hoffman, PhD
Radiology

Gail Bishop, PhD
Microbiology

A. Brent Carter, MD
Internal Medicine

Alejandro Comellas, MD (associate member)
Internal Medicine

Beverly L. Davidson, PhD
Anatomy and Cell Biology

Lakshmi Durairaj, MD

Internal Medicine

John Engelhardt, PhD
Internal Medicine

Alicia Gerke, MD, MBA (associate member)
Internal Medicine

Paul B. McCray, Jr., MD
Internal Medicine

Martha M. Monick, PhD
Internal Medicine

William M. Nauseef, MD
Internal Medicine

Paul B. Rothman, MD
Internal Medicine

Fayyaz S. Sutterwala, MD, PhD
Internal Medicine

Peter S. Thorne, PhD

Occupational & Environmental Health

Jerrold P. Weiss, MD
Internal Medicine & Microbiology

Michael J. Welsh, MD
Internal Medicine

Joseph Zabner, MD
Internal Medicine