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Specific AimsAim I. Determine whether mortality (death) rates of IAAAP workers are higher than expected. Researchers will analyze U.S. and Iowa death records to determine whether overall mortality or cause-specific mortality (e.g., diseases of the heart, liver, kidney, lung, etc.) rates are higher among IAAAP workers. This aim will help determine whether or not IAAAP operations contributed to increases in mortality among workers. In addition, the findings may provide information on previously unrecognized hazards, so appropriate workplace interventions can be Aim II. Determine whether IAAAP workers experience higher cancer rates compared to other Iowans. Researchers will analyze Iowa cancer records to determine whether IAAAP workers are at higher risk for overall cancer incidence as well as certain site-specific cancers, compared to unexposed Iowa workers. This aim will help determine whether or not IAAAP operations contributed to increases in cancer incidence among workers. In addition, the findings may provide information on previously unrecognized hazards, so appropriate workplace interventions can be made and medical screening services provided. Aim III. Determine whether IAAAP workers are at higher risk for beryllium sensitization (BeS) compared to a non-beryllium-exposed population. Researchers will determine the prevalence of and risk factors for BeS by testing a subset of current and former workers who represent different job categories, work practices, and job descriptions. Selected individuals will be asked to provide blood specimens to be analyzed for BeS. This aim will help assess what job categories and tasks were at risk for BeS, and if cases of chronic beryllium disease have occurred in the IAAAP workforce. The study will offer medical evaluation to those workers with confirmed BeS. |
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